Dolutegravir Lamivudine and Tenofovir Disoproxil Fumarate tablets are used in combination with other antiretroviral medications to treat HIV (human immunodeficiency virus) infection. This combination medication works by preventing HIV from multiplying and spreading, helping to reduce the amount of HIV in the body. This can decrease the risk of serious HIV-related health problems such as AIDS.

Dolutegravir/lamivudine/tenofovir

This article is about the combination medication dolutegravir/lamivudine/tenofovir disoproxil. For the combination medication dolutegravir/lamivudine/tenofovir alafenamide, see Tenofovir alafenamide § combinations.

Dolutegravir/lamivudine/tenofovir (DTG/3TC/TDF) is a fixed-dose combination antiretroviral medication used to treat HIV/AIDS. It is a combination of dolutegravir, lamivudine, and tenofovir disoproxil. As of 2019[update], it is listed by the World Health Organization (WHO) as the first line treatment for adults, with tenofovir/lamivudine/efavirenz as an alternative. It is taken by mouth.

Side effects may include trouble sleeping, weight gain, and rash. While there are concerns that use during pregnancy results in a 0.2% increased risk of neural tube defects in the baby, this does not rule out its use. Use remains recommended after the first trimester. Use is not recommended in those with kidney problems. The combination is a type of antiretroviral therapy.

It is on the World Health Organization’s List of Essential Medicines. In some countries it is available as a generic medication. It is tentatively approved in the United States as of 2019, full approval is pending expiration of the US patents on dolutegravir (Tivicay) and tenofovir disoproxil (Viread).

Medical uses

As of 2019, it is listed by the World Health Organization (WHO) as the first-line treatment for adults with HIV/AIDS, with tenofovir/lamivudine/efavirenz as an alternative. It may be used in people with both HIV and tuberculosis, however if the person is on rifampicin a larger dose of dolutegravir is needed.

Side effects

Side effects may include trouble sleeping and weight gain. While there are concerns that use during pregnancy results in a 0.2% increased risk of neural tube defects in the baby, this does not rule out its use. Use remains recommended after the first trimester. It should not be used with dofetilide.

Society and culture

Economics

In the developing world it costs about US$75 per year. It is considered more cost effective than tenofovir/lamivudine/efavirenz as of 2019.

References

External links

Antiviral drugs: antiretroviral drugs used against HIV (primarily J05)
Capsid inhibitors Entry/fusion inhibitors
(Discovery and development) Integrase inhibitors
(Integrase strand transfer inhibitors (INSTI)) Maturation inhibitors Protease Inhibitors (PI)
(Discovery and development)
1st generation
2nd generation
Reverse-transcriptase
inhibitors
(RTIs)
Nucleoside and
nucleotide (NRTI)
Non-nucleoside (NNRTI)
(Discovery and development)
1st generation
2nd generation
Combined formulations
Pharmacokinetic boosters Experimental agents
Uncoating inhibitors
Transcription inhibitors
Translation inhibitors
BNAbs
Other
Failed agents

°DHHS recommended initial regimen options. Formerly or rarely used agent.


Source: Dolutegravir/lamivudine/tenofovir
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